body·mind·state
← Back to Research
research

Nitric Oxide-Mediated Minimally Invasive Neuromodulation through Gut-Brain Axis via a Bioelectronic Microdevice for Relieving Depressive Symptoms

Minimally invasive brain modulation is essential for understanding and treating neurological disorders. This study presents a wireless, optically controlled nitric oxide (NO)-releasing microbioelectronic device (ONMD) that enables peripheral-to-centr...

BMS
Body Mind State EditorialJune 30, 2026 · 1 min read

Key Findings

Minimally invasive brain modulation is essential for understanding and treating neurological disorders. This study presents a wireless, optically controlled nitric oxide (NO)-releasing microbioelectronic device (ONMD) that enables peripheral-to-central neuromodulation without direct brain intervention. Upon light activation, the ONMD releases NO to locally activate transient receptor potential (TRP) channels, forming a confined NO-TRP signaling hub that selectively stimulates the vagus nerve and activates the nucleus tractus solitarius (NTS), a key brainstem center involved in autonomic and reward regulation. Through this hierarchical pathway, the ONMD-mediated neuromodulation alleviates depressive-like behaviors in mice, accompanied by reduced peripheral inflammation and restored central serotonin (5-HT) homeostasis. Operating in the intestine, the ONMD achieves remote modulation of central circuits through peripheral access. This gasotransmitter-mediated, multilevel bioelectronic approach offers a noninvasive strategy for regulating brain function and advancing neuropsychiatric therapies.

Why This Matters for Body-Mind Practice

[Draft — editorial context needed]

Source

Continue Reading

research

Mechanisms Underlying Burning Mouth Syndrome and Occlusal Dysesthesia: Shared and Distinct Pathways of Oral Sensory Dysregulation

Burning mouth syndrome (BMS) and occlusal dysesthesia (OD) are chronic oral sensory disorders that present without evident local pathology yet frequently cause substantial diagnostic and therapeutic challenges in oral medicine practice. Although both...

1 min read research

Comparative response patterns and tolerability of high-frequency rTMS in unipolar versus bipolar depression: a retrospective naturalistic study

This retrospective naturalistic study compared response patterns and tolerability of high-frequency left-DLPFC repetitive transcranial magnetic stimulation (rTMS) in patients with major depressive disorder (MDD) and bipolar depressive disorder (BD) u...

2 min read research

Cross-cultural translation, adaptation, and validation of the Chinese versions of the athlete fear avoidance questionnaire and fear of return to sport scale

Sports injuries not only impose periods of physical rest, but they can also provoke negative psychological responses, particularly fear, that can delay return to sport (RTS) and elevate reinjury risk. Although various instruments, including the Athle...

1 min read