Effectiveness of preoperative pulmonary rehabilitation in patients with lung cancer combined with moderate to severe COPD: study protocol for a randomized controlled trial
The aim of this study is to evaluate the effectiveness of preoperative pulmonary rehabilitation in lung cancer patients with moderate to severe COPD by a randomized controlled trial protocol, and to explore the effect of preoperative pulmonary rehabi...
Key Findings
The aim of this study is to evaluate the effectiveness of preoperative pulmonary rehabilitation in lung cancer patients with moderate to severe COPD by a randomized controlled trial protocol, and to explore the effect of preoperative pulmonary rehabilitation on surgical outcomes in high-risk patients METHODS: A randomized, prospective, single-blind (evaluator) clinical trial. Participants(n=70) will be randomly divided into two groups. The intervention group will receive 2 weeks preoperative pulmonary rehabilitation program (inspiratory muscle training + aerobic exercise + preoperative rehabilitation education), the control group will only receive preoperative rehabilitation education. Both groups will routinely receive the guidance training (contains breathing exercises and early ambulation) after surgery. The primary outcome is incidence of PPCs defined with the Melbourne Group Scale diagnostic scoring tool. Secondary outcomes include pre- and post-operative hospital length of stay (LOS), cardiopulmonary endurance, muscle strength, inspiratory muscle strength,pulmonary function,health-related quality of life (HRQoL), fatigue, the sleep quality ,anxiety and depression. This trial was designed to test the hypothesis that preoperative pulmonary rehabilitation can improve preoperative cardiopulmonary function of patients with lung cancer complicated with moderate and severe COPD, reduce the incidence of PPCs, shorten the length of hospitalization, Improve fatigue, quality of life and more. Chinese Clinical Trial Registry:ChiCTR2400093829,12 December 2024.
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